Photo-activation of the hydrophobic probe iodonaphthylazide in cells alters membrane protein function leading to cell death

Table 1 Cytotoxic activity of INA-UV treatment measured on different cancer cell lines by the MTS assay

Cell line	Human cancer types	IC₅₀ ± SE (μM)*
MCF7	Breast adenocarcinoma	20.6 ± 8.8
HeLa	Cervical cancer	11.2 ± 1.7
U251	Glioma	15.4 ± 1.0
SKOV-3	Ovarian carcinoma	17.6 ± 1.0
SKBR-3	Breast carcinoma	7.8 ± 1.5
KB3-1	Epidermoid carcinoma	16.0 ± 0.7
KBV1	Epidermoid carcinoma overexpressing Pgp	12.3 ± 4.4
293	Epithelial cell line from embryonic kidney	8.6 ± 0.9
293/MRP1	Epithelial cell line from embryonic kidney overexpressing MRP1	7.3 ± 1.0
SupT1	T lymphoblastoid	4.9 ± 0.6

* Seven independent measurements were performed and analyzed together. IC₅₀ values were computed by fitting a four-parameter nonlinear regression model with R statistical software [57]. The standard error (SE) represents the 95% confidence interval.

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