Figure 5
From: Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis
The effect of compound 1 on BAEC tube formation in Matrigel with and without FGF-2. (A) Compound 1 inhibited FGF-2 (25 ng/ml) induced BAEC differentiation into capillary like structures: column1, control. In the absence of FGF-2 there was no inhibitory effect on tube formation. Values significantly different from FGF-2 alone (p < 0.05) are shown by *. Results are the mean of three experiments (B) Representative photomicrographs (original magnification × 20) show tube formation by BAEC. In the presence of FGF-2 a closed tubular network was evident (an example is shown in II) and this was abolished by compound 1 (shown in IV). In the control (I0 and with compound 1 alone (III) there was no evidence of tube formation.