Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family

Table 1 Alignment scores of MarvelD3 sequences from different vertebrates

	H. sapiens isoform 1NM_001017967	H. sapiens isoform 2NM_052858	M. musculus isoform 1NM_212447	M. musculus isoform 2NM_028584	C. lupus f. Isoform 1XM_848243	C. lupus f. Isoform 2XM_546843	X. laevis Variant ABC_068841	G. gallus Variant AXM_418989	G. gallus Variant BXM_414239
H. sapiens isoform 2 NM_052858	63	100
M. musculus isoform 1 NM_212447	72	40	100
M. musculus isoform 2 NM_028584	43	68	61	100
C. lupus f. Isoform 1 XM_848243	71	39	67	39	100
C. lupus f. Isoform 2 XM_546843	40	69	38	68	61	100
X. laevis Variant A BC_068841	25	43	24	42	23	44	100
G. gallus Variant A XM_418989	30	51	28	48	28	50	44	100
G. gallus Variant B XM_414239	30	24	30	21	28	22	23	24	100
D. rerio Variant A BC_055662	25	40	26	37	23	40	39	31	25

MarvelD3 sequences were retrieved from Genbank and aligned using ClustalW (see Fig. 1 for a selection of the alignments). Indicated are all Genbank accession numbers. The scores reflect percent identity. For mammals, the two alternatively spliced isoforms were used. Two different MarvelD3 genes, variants A and B, exist in chicken. Only variant A was found in X. laevis and zebrafish.

ISSN: 2661-8850