Molecule | control 0 h | 0.25 h | 0.5 h | 1 h | 3 h | 6 h |
---|---|---|---|---|---|---|
integrin β3 (Int β3) | / | ± 0 | ± 0 | ± 0 | ± 0 | +32.2% * p < 0.01 |
focal adhesion kinase (FAK) | / | ± 0 | ± 0 | ± 0 | ± 0 | + 28.7% * p < 0.01 |
phosphorylated focal adhesion kinase (pFAK) | / | + 12.8% * p < 0.01 | ± 0 | ± 0 | ± 0 | ± 0 |
p42/44 | / | + 5.8% * | + 12.5% * p < 0.01 | ± 0 | - 9.0% * p < 0.01 | + 0.2% * |
phosphorylated p42/44 | / | + 2.3% * | - 7.3% * | -10.0% * p < 0.01 | + 0.5% * | + 10.2% * p < 0.01 |
phosphorylated p42/44 + inhibitor | / | / | / | / | / | maximum inhibition - 16.0% ⊗ p < 0.01 |
p38 | / | - 5.3% * p < 0.01 | - 13.8% * p < 0.01 | - 9.6% * p < 0.01 | - 3.1% * | + 26.2% * p < 0.01 |
phosphorylated p38 | / | + 5.7% p < 0.01 | - 1.7% | + 3.1% | + 0.9% | + 11.4% p < 0.01 |
phosphorylated p38 + inhibitor | / | / | / | / | / | maximum inhibition - 62% ⊗ |
matrix metalloproteinase 13 (MMP13) | / | + 8.4% * p < 0.01 | + 1.4% * | +1.53% * | + 0.7% * | + 16.0% * p < 0.01 |
matrix metalloproteinase 13 (MMP13) + pp38 inhibitor | - 11.0% ⊗ p < 0.01 | - 17.0% ⊗ p < 0.01 | - 18.8% ⊗ p < 0.01 | - 13.5% ⊗ p < 0.01 | - 12.0% ⊗ p < 0.01 | - 25.7% ⊗ p < 0.01 |
matrix metalloproteinase 13 (MMP13) + pp42/44 inhibitor | - 22.6% ⊗ p < 0.01 | - 28.6% ⊗ p < 0.01 | - 24.3% ⊗ p < 0.01 | - 24.8% ⊗ p < 0.01 | - 24.3% ⊗ p < 0.01 | -34.1% ⊗ p < 0.01 |