A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling

Table 1 Chaperone level in MLE-12 cells expressing mutant SP-C^I73T in response to drugs used in ILD therapy.

	HSP 90	Calreticulin	HSP 70	Calnexin
Cyclophosphamide	+ 30% *	+ 13% *	+ 41% *	+ 16%
Azathioprine	+36% *	+ 8%	+ 7%	- 13%
Hydroxychloroquine	+ 81% *	+ 75% *	+ 18%	+ 6%
Methylprednisolone	+ 55% *	+ 26% *	+ 8%	- 9%

Presented are the results of three independent experiments and expressed as % changes of the protein amounts in SP-C^I73T cells compared to SP-C^WT expressing cells; * denotes p-values < 0.05

ISSN: 2661-8850