Dg-Dys-Syn1 signaling in Drosophila regulates the microRNA profile

Table 1 DGC interactors are putative Dg-Dys-Syn1 regulated miRNA targets

Gene name	Symbol	Function	Targeting miRNA*	Interaction
				Dg	Dys
Dystrophin	Dys	Main DGC component	miR-252	w, m	-
Dystroglycan	Dg	Extra- intracellular signaling	miR-252	-	w, m
Dystroglycan	Dg	Extra- intracellular signaling	miR-980	-	w, m
Syntrophin-like 1	Syn1	structural constituent of muscle; cytoskeletal protein binding	miR-252	nt	nt
Calmodulin	Cam	Ca²⁺ dependent pathways regulation	miR-252*	-	w, m
Kinesin heavy chain	Khc	microtubule motor activity	miR-252*	-	w
Sema-2a	Sema-2a	protein binding	miR-252	w	w
Sema-1a	Sema-1a	protein binding	miR-252*	w	w
frazzled	fra	netrin receptor	miR-252	-	w
roundabout	robo	Heparin/protein binding	miR-252	w, m	w, m
Syndecan	Sdc	transmembrane receptor	miR-980*	-	w
starry night	stan	receptor signaling	miR-252*	w	w
Delta	Dl	Notch binding	miR-252	w	w
Delta	Dl	Notch binding	miR-980*	w	w
Daughters against dpp	Dad	TGF-β receptor	miR-252*	w	w
thickveins	tkv	TGF-β receptor	miR-252*	-	w
homeodomain interacting protein kinase	hipk	β-catenin binding; transcription factor binding; protein serine/threonine kinase	miR-980*	-	w
homeodomain interacting protein kinase	hipk		miR-956*	-	w
kismet	kis	ATP-dependent helicase	miR-252	w	w
CG4496	CG4496	zinc ion binding; nucleic acid binding	miR-252*	-	w
Plenty of SH3s	POSH	ubiquitin-protein ligase	miR-252	w	w
visceral mesodermal armadillo-repeats	vimar	Ral GTPase binding	miR-252	w, m	w
uninflatable	uif	Notch binding	miR-980*	-	w

ISSN: 2661-8850