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Table 2 Summary of changes in several important parameters involved in high glucose induced protein aggregation in ZDF brain and the effect of NaHS on them

From: Increased protein aggregation in Zucker Diabetic Fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide

Parameters analyzed

ZDF brain

NaHS + ZDF brain

ROS levels

↑

↓

Protein aggregates

↑

↓

Protein synthesis (mTOR, S6)

↑

↓

FABP

↓

—

Thiols

↓

↑

CBS

↓

—

CML expression

↑

↓

UB-proteins

↑

↓

Autophagy

↓ (LC3-II↓, LC3-I↑)

↑ (LC3-II↓, LC3-I↓)

Tau and p-tau

↑

↓

Fibronectin

↑

↓

  1. ZDF brain was compared to lean brain as control and NaHS treated ZDF brain was compared to ZDF brain as control. The arrows indicate the changes in each parameter.