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Figure 6 | BMC Cell Biology

Figure 6

From: Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function

Figure 6

GPR40 activation and β-cells survival. (A) Phosphorylated Akt levels were measured by western blotting of NIT1 cells cultured for 72 h as indicated. Total Akt levels were measured for normalization. Chronic inflammation down-regulated expression of bcl2 (B) and pdx1 (D) whereas it up-regulated expression of cdkn1a (C) gene in rat islets. Activation of GPR40 partially reversed expression of these genes. Gene expression was quantified by qRT-PCR. (n = 4, *P < 0.05, **P < 0.01, ***P < 0.001).

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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