Table 1 Growth inhibitory effect of vasicinone analogues, BEZ-235 and 5-Flurouracil against panel of human cancer cell lines
From: Cell specific apoptosis by RLX is mediated by NFκB in human colon carcinoma HCT-116 cells
Tissue type | Leukemia | Prostate | Breast | Pancreas | Colon | Epithelial (Normal) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Cell type | THP-1 | PC-3 | T47D | MCF-7 | MIAPaca 2 | HCT-116 | Caco-2 | fR-2 | ||
S. No | Structure | Conc (μM) | % Growth inhibition | |||||||
1 |
| 50 | 53 ± 2 | 30 ± 3 | 66 ± 2 | 68 ± 2 | 53 ± 3 | 96 ± 1 | 30 ± 3 | 20 ± 2 |
30 | 52 ± 3 | 29 ± 2 | 55 ± 1 | 54 ± 1 | 40 ± 5 | 82 ± 1 | 26 ± 4 | 14 ± 1 | ||
20 | 44 ± 4 | 21 ± 1 | 42 ± 0 | 42 ± 2 | 31 ± 4 | 79 ± 2 | 20 ± 5 | 12 ± 2 | ||
10 | 32 ± 2 | 12 ± 4 | 12 ± 5 | 32 ± 1 | 14 ± 3 | 37 ± 2 | 10 ± 2 | 8 ± 1 | ||
5 | 4 ± 1 | 5 ± 3 | 6 ± 2 | 11 ± 1 | 5 ± 2 | 4 ± 1 | 5 ± 1 | 3 ± 2 | ||
2 |
| 50 | 42 ± 1 | 30 ± 2 | 49 ± 3 | 33 ± 3 | 47 ± 3 | 43 ± 3 | 10 ± 3 | 10 ± 2 |
30 | 40 ± 2 | 23 ± 3 | 42 ± 2 | 20 ± 3 | 41 ± 2 | 27 ± 1 | 3 ± 2 | 6 ± 1 | ||
20 | 33 ± 2 | 11 ± 2 | 35 ± 3 | 11 ± 3 | 39 ± 3 | 20 ± 1 | 2 ± 2 | 4 ± 2 | ||
10 | 20 ± 1 | 7 ± 2 | 30 ± 3 | 1 ± 1 | 18 ± 2 | 18 ± 2 | 1 ± 3 | 1 ± 1 | ||
5 | 8 ± 2 | 1 ± 3 | 10 ± 1 | 1 ± 1 | 9 ± 1 | 11 ± 3 | 1 ± 3 | 1 ± 2 | ||
3 |
| 50 | 45 ± 1 | 37 ± 3 | 30 ± 3 | 5 ± 1 | 44 ± 3 | 29 ± 1 | 10 ± 3 | 12 ± 1 |
30 | 42 ± 2 | 29 ± 1 | 22 ± 2 | 2 ± 1 | 30 ± 2 | 29 ± 3 | 8 ± 2 | 10 ± 1 | ||
20 | 6 ± 2 | 10 ± 2 | 21 ± 1 | 2 ± 2 | 15 ± 1 | 21 ± 2 | 3 ± 3 | 6 ± 2 | ||
10 | 4 ± 1 | 9 ± 1 | 4 ± 1 | 1 ± 1 | 11 ± 3 | 21 ± 2 | 1 ± 1 | 2 ± 1 | ||
5 | 3 ± 3 | 8 ± 2 | 1 ± 3 | 1 ± 1 | 10 ± 2 | 5 ± 3 | 1 ± 2 | 3 ± 1 | ||
4 |
| 50 | 30 ± 3 | 40 ± 1 | 20 ± 2 | 49 ± 2 | 12 ± 1 | 30 ± 2 | 10 ± 1 | 20 ± 1 |
30 | 22 ± 1 | 27 ± 2 | 10 ± 1 | 40 ± 1 | 10 ± 2 | 23 ± 1 | 10 ± 2 | 16 ± 2 | ||
20 | 21 ± 3 | 20 ± 1 | 8 ± 1 | 19 ± 3 | 6 ± 1 | 11 ± 3 | 7 ± 1 | 14 ± 1 | ||
10 | 4 ± 1 | 18 ± 1 | 7 ± 1 | 10 ± 1 | 2 ± 1 | 7 ± 3 | 5 ± 1 | 11 ± 2 | ||
5 | 2 ± 2 | 11 ± 3 | 2 ± 1 | 4 ± 2 | 1 ± 3 | 1 ± 3 | 2 ± 3 | 10 ± 1 | ||
5 | BEZ-235 | 10nM | - | - | 50 ± 2 | - | 53 ± 4 | 51 ± 1 | - | 26 ± 1 |
6 | 5-Flurouracil | 20 μM | - | - | - | - | - | 62 ± 1 | - | 70 ± 2 |
