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Table 1 Modulation of P-gp expression by agents that induce astroglial reactivity.

From: Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF

Treatment

Concentration

Effect

dBcAMP

0,5 mM

- 3.1 ± 8

IL-1β

50 ng/ml

+10.5 ± 11

Lesion

/

- 12.1 ± 8

LPS

1 μg/ml

+ 2.3 ± 8

NGF

10 ng/ml

- 21.7 ± 22

RA

10-7 M

- 28.6 ± 20.2

rhIFN-β

600 U/ml

-20 ± 11

rhIFNγ

rhTGFα

300 U/ml

50 ng/ml

+50 ± 30

-9 ± 5

TNFα

100 ng/ml

+ 7.6 ± 9.1

rhCT-1

10 ng/ml

+ 69.6 ± 24 **

rhLIF

30 ng/ml

+ 54.3 ± 12 **

rmIL-6

40 ng/ml

+68.8 ± 10 ***

RmIL-6

50 ng/ml

+220.28 ± 22 ***

+

  

rhsIL-6R

500 ng/ml

 

rrCNTF

250 ng/ml

+ 75.7 ± 30 *

  1. *: ANOVA significant at 95%, t-test p < 0.05; **: ANOVA significant at 95%, t-test p < 0.01; ***: ANOVA significant at 95%, t-test p < 0.001.