Figure 5

Hierarchical cluster analysis of cytosolic and cytoskeleton-associated transcriptome profiles in promyelocytic and differentiated HL-60. Complete linkage clustering by Euclidean distance was performed to compare the four sets of transcripts (cytosolic versus cytoskeleton transcripts in HL-60 cells in the presence or absence of phorbol ester). The cytoskeleton-associated populations in promyelocytic and phorbol ester-induced differentiated cells cluster most closely together, suggesting that the spatial distribution of cytoskeleton-associated transcripts may be largely conserved across different cell types.