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Table 1 A comparison between native (nAAT) and polymerised (pAAT) α1-antitrypsin (0.1 mg/ml) effects on cytokine and chemokine release.

From: Concentration-dependent effects of native and polymerised α1-antitrypsin on primary human monocytes, in vitro

 

IL-6 (pg/ml)

TNFα (pg/ml)

 

nAAT

pAAT

nAAT

pAAT

Mean

66.14

193.8

29.4

13.8

SD

2.6

6.04

1.2

1.8

t-value

33.7

12.5

Df

2.7

3.5

p-value

<0.001

<0.001

nAAT/pAAT

  

2.1

pAAT/nAAT

2.9

  
 

IL-8 (pg/ml)

MCP-1 (pg/ml)

 

nAAT

pAAT

nAAT

pAAT

Mean

68.9

379.8

166.0

92.2

SD

0.40

10.4

27.0

3.6

t-value

51.7

4.7

Df

2.0

2.1

p-value

<0.001

<0.01

nAAT/pAAT

  

1.8

pAAT/nAAT

5.5

  
  1. Mean-values of six separate experiments SD-standard deviation, Df-degree of freedom, t-value, calculated using Walsh t test [52].