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Figure 3 | BMC Cell Biology

Figure 3

From: Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression

Figure 3

ER degradation limits untagged mOREG functional expression. CNG cells transiently transfected with untagged mOREG were assayed for increases in intracellular calcium in response to increasing concentrations of eugenol (from 3 uM to 1000 uM) following treatment with vehicle (control), 10 mM 3-MA, or 50 uM MG-132 for 4 h. The EC50 values for eugenol for control (36.5 +/- 12.9 uM), 3-MA (42.6 +/- 6.5 uM), and MG-132 (36.4 +/- 7.5 uM) treatments were not significantly different. CNG cells transfected with vector only (pUC18) and treated with vehicle, 3-MA, or MG-132 did not respond to 1000 uM eugenol.

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