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Figure 4 | BMC Cell Biology

Figure 4

From: Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression

Figure 4

Simultaneous inhibition of autophagy and the proteasome does not produce additive Rho-mOREG functional responses. CNG cells transiently transfected with Rho-mOREG were assayed for increases in intracellular calcium in response to 10 uM eugenol following treatment with vehicle (control), 10 mM 3-MA, 50 uM MG-132, or 10 mM 3-MA plus 50 uM MG-132 for 4 h. Individual or combined treatment with degradation inhibitors yielded similar levels of Rho-mOREG activity. * p < 0.001 compared to cells treated with vehicle.

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