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Figure 1 | BMC Cell Biology

Figure 1

From: Contribution of gap junctional communication between tumor cells and astroglia to the invasion of the brain parenchyma by human glioblastomas

Figure 1

Heterocellular coupling of glioma cell lines, and migration assay in brain slice cultures. A, heterocellular coupling between astrocytes and human glioma cell lines (using the preloading method, see also fig. 6A). In contrast to 8-MG cells, GL15 cells established extensive GJC with normal astrocytes. Histograms represent mean heterocellular coupling indices (number of recipient astrocytes per double labeled tumor cell) of a minimum of three independent experiments (range 4 – 6; n= 120 to 225 donor cells per group; ± SEM; ***, p < 0.001). B, 8-MG cells and GL15 cells migration in brain slice cultures. Histograms of the average migration indices showing that GL15 were more invasive than 8-MG cells (mean values ± SEM. ***, p < 0.001).

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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