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Figure 2 | BMC Cell Biology

Figure 2

From: Microtubules regulate disassembly of epithelial apical junctions

Figure 2

Depolymerization of microtubules blocks disassembly and internalization of apical junctions in different epithelial cell lines. Similarly to SK-CO-15 cells, T84, Caco-2 and MDCK cell lines readily respond to 1 h calcium depletion by translocating junctional proteins β-catenin, occludin and ZO-1 from areas of cell-cell contacts into cytosolic ring-like structures. Depolymerization of microtubules with nocodazole (30 μM) inhibits disassembly of the AJC and translocation of junctional proteins in all tested epithelial cell lines. Bar, 10 μm.

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