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Figure 6 | BMC Cell Biology

Figure 6

From: Microtubules regulate disassembly of epithelial apical junctions

Figure 6

Kinesin microtubule motors mediate disassembly/internalization of AJs and TJs and regulate contraction of F-actin rings. SK-CO-15 cells were incubated for 1 h in calcium-free media in the presence of either vehicle or kinesin inhibitors 5' -adenylylimidodiphosphate (AMP-PNP, 500 μM) or aurintricarboxylic acid (ATA, 50 μM). Note that inhibition of kinesin motor activity blocks contraction of F-actin rings and translocation of E-cadherin and occludin into subapical cytosolic rings. Bar, 10 μm.

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