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Figure 7 | BMC Cell Biology

Figure 7

From: D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells

Figure 7

Comparison of the MEKK family: phylogenetic history and conserved domains. (A) Multiple sequence alignment of the MEKK family (including D-MEKK1a and D-MEKK1b, two alternatively-spliced variants of D-MEKK1 [38]) was done using Clustal X. Phylogeny was analyzed using Phylip and displayed using TreeView program. (B) Graphic representation of the selective divergence between the N-terminal regulatory domains and the C-terminal kinase domains of mammalian MEKKs from their Drosophila homologue D-MEKK1. Abbreviations (both A and B) are: Dm, Drosophila melanogaster, Hs, Homo sapiens, Mm, Mus musculus; PPP, proline-rich motif, PH, plekstrin homology motif, RB, Ras-binding motif, CRIB, cdc42/Rac-interactive binding motif.

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