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Table 1 Percentage of CpG methylation in the LEP, PPARG2, FABP4 and LPL promoters in undifferentiated and differentiated ASC clones at passage 4 (P4) and at senescence (Ps)

From: Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence

  

Percent methylated cytosines in promoter region examined

Gene

 

LEP

PPARG2

FABP4

LPL

Passage No.

 

P4

Ps

P4

Ps

P4

Ps

P4

Ps

Undifferentiated

         

ASC clone

B1

9

17a

10

20c

15

45a

20

8a

 

B2

7

14a

15

18ns

30

25ns

27

26ns

 

B3

24

24ns

29

23ns

50

75a

19

19ns

Differentiated

         

ASC clone

B1

13

13ns

5

33a

12

13ns

17

11ns

 

B2

4

17a

17

25c

22

25ns

29

24ns

 

B3

22

38a

17

22ns

50

70b

18

14ns

  1. Chi-square tests: a P < 0.001; b P < 0.005; c P < 0.05; ns non-significant.