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Table 1 GSK-3 inhibitors used in this study

From: GSK-3 inhibitors induce chromosome instability

Compound

Class

Mechanism

In vitro IC50

Conc. used in cells

Ref.

SB-415286

Arylindole-maleimides

ATP Competitor

78 nM

30 μM

[44]

AR-A014418

Thiazole

ATP Competitor

104 nM

20 μM

[58]

1-Aza kenpaullone

Benzazepinone

ATP Competitor

18 nM

2.5 μM

[57]

CHIR99021

Aminopyrimidine

ATP Competitor

7 nM

10 μM

[47]

Lithium

Divalent ion

Non competitive

2 mM

40 mM

[41]

TDZD-8

Thiadiazolidinone

Non competitive

2 μM

10–60 μM

[70]

Inhibitor II

Pyridyloxadiazole

-

390 nM

25–75 μM

[71]

OTDZT

Thiadiazolidinone

Non competitive

10 μM

50–100 μM

[70]

Inhibitor XI

Azaindolylmaleimide

ATP Competitor

32 nM

50 μM

[72]