Figure 1From: The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesisSchematic representation of mNek1 depicting major features of the primary structure of the protein. Numbers indicate amino acid position in the primary sequence of mNek1 (mRNA, AY850065; protein, AAB23529). Major features include: N-terminal kinase domain (light green, residues 1–258), a basic domain (pI = 10.21, light blue, residues 258–353), a coiled-coil domain (light orange, residues 353–686) containing four coiled-coils (red, CC1–CC4, residues indicated), a fifth coiled-coil in the C-terminus (red, CC5), a predicted NLS (blue, residues 355–378) and two predicted NESs (yellow, 764–774 and 1131–1138). Although the full-length sequence of mNek1 has a predicted isoelectric point of 5.45, the sequence can be divided into a basic N-terminus (Basic Region, pI = 9.61, residues 1–686) and an acidic C-terminus (Acidic Region, pI = 4.33, residues 686–1203).Back to article page