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Figure 1 | BMC Cell Biology

Figure 1

From: The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesis

Figure 1

Schematic representation of mNek1 depicting major features of the primary structure of the protein. Numbers indicate amino acid position in the primary sequence of mNek1 (mRNA, AY850065; protein, AAB23529). Major features include: N-terminal kinase domain (light green, residues 1–258), a basic domain (pI = 10.21, light blue, residues 258–353), a coiled-coil domain (light orange, residues 353–686) containing four coiled-coils (red, CC1–CC4, residues indicated), a fifth coiled-coil in the C-terminus (red, CC5), a predicted NLS (blue, residues 355–378) and two predicted NESs (yellow, 764–774 and 1131–1138). Although the full-length sequence of mNek1 has a predicted isoelectric point of 5.45, the sequence can be divided into a basic N-terminus (Basic Region, pI = 9.61, residues 1–686) and an acidic C-terminus (Acidic Region, pI = 4.33, residues 686–1203).

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