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Fig. 4 | BMC Cell Biology

Fig. 4

From: The role of neural connexins in HeLa cell mobility and intercellular communication through tunneling tubes

Fig. 4

Characterization of electrical properties of TTs formed between HeLa wt and Cx36-EGFP-, Cx40-CFP-, Cx43-EGFP-, Cx45-, and Cx47-expressing cells. a The TT connecting a pair of HeLa Cx45 cells. b Electrical properties of TTs were evaluated by applying a voltage ramp of negative polarity from 0 to −120 mV (b, upper panel) to the cell-1 and measuring junctional current in the cell-2 (b, middle panel demonstrates a typical IT response of open-ended TTs, and lower panel, of GJ containing TTs); c Typical gT-VT dependences of open-ended (black) and GJ-containing (red) TTs calculated from IT responses to VT ramps shown in (b) with their symmetric counterparts. d Summary of conductances of TTs between HeLa wt and different Cx-expressing cells (the number of experiments is indicated on the bars; exact numbers are presented in Table 1). *p < 0.05

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