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Fig. 1 | BMC Cell Biology

Fig. 1

From: Spatiotemporal patterns of sortilin and SorCS2 localization during organ development

Fig. 1

Sortilin expression in embryonic respiratory tract. Immunofluorescence was performed on sagittal sections (10 μm) of embryos on embryonic day E13.5 (d), E15.5 (a, b, d, e) and E17.5 (c, f). Sortilin localizes prominently to the epithelium and glands of the nasal cavity (a, c) and is also found in the tracheal epithelium (b). Furthermore, sortilin is highly expressed in the apical part of the epithelium of the branching bronchial network at all three time points investigated. The expression is confined primarily to distal branches and is diminished in proximal more mature bronchi (d, e). Green channel is sortilin, red channel is calretinin (a) or TTF-1 and blue channel is Hoechst nuclear stain. Scale bars = 50 μm. Br, bronchus; Ca, cartilage; Db, distal branch; Gl, epithelial gland; Na, nasal cavity; Ol, olfactory epithelium; Pl pleuric cavity; Tr, tracheal epithelium

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