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Fig. 3 | BMC Cell Biology

Fig. 3

From: Connexins: substrates and regulators of autophagy

Fig. 3

Endolysosomal degradation: CIP85 interacts with Cx43 via SH3 domain at plasma membrane. Initiation of clathrin-mediated endocytosis starts at PtdIns(4,5)P2-rich sites in the plasma membrane where the AP2 adaptor complex associates and recruits further accessory proteins. AP2 complexes connect the cargo membrane protein to clathrin coat. GTPase dynamin is necessary for movement of the vesicle and cargo into the cell. Internalized Cx43 are degraded via lysosomal degradation

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