Fig. 5From: New STAT3-FOXL2 pathway and its function in cancer cellsSummary of STAT3-FOXL2 signaling function in HeLa cell growth and apoptosis. Phosphorylated-STAT3 enters the cell nucleus from the cytoplasm and binds to the confirmed new binding sites, which are located in the promoter region of FOXL2, then up-regulates the expression of TNF, and down-regulates the expression of GnRHR and TRAIL. Finally, the cancer cell growth inhibition and apoptosis are inhibitedBack to article page