Fig. 9
From: CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches
a and b: (a) Model of potential ternary complex of agonist FAB516 Fab (cyan), human CD40 (green), human CD40L (purple). Box outlines region where minor structural rearrangements may occur to accommodate agonist complex. (b) After ternary complex minimization in MAESTRO, HCDR2 (S52-G56) and CD40L (S128-K132) residues shift to accommodate the interface between CD40L, FAB516 and CD40