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Fig. 5 | BMC Molecular and Cell Biology

Fig. 5

From: Remote homology searches identify bacterial homologues of eukaryotic lipid transfer proteins, including Chorein-N domains in TamB and AsmA and Mdm31p

Fig. 5

Homologies between N-termini of DUF2993 AsmA, TamB and Chorein-N. a Secondary structural elements in residues 1–124 of the M. tuberculosis DUF2993 protein Rv0817c, also showing the confidence of the structural prediction by PSI-PRED (range 0–9, transmembrane domain excluded). b HHpred hits in PFAM for the N-terminus of Rv0817c. After identifying itself, the next hit is DUF2125 (ppSS = 56%, 57 columns), and the third hit is Chorein-N (ppSS = 45%, 37 columns). c All vs. all pairwise alignments of the N-terminus of Rv0817c, Chorein-N, Mdm31p (residues 131–312) and the N-termini of AsmaA and TamB (130, 115, 182, 180 and 150 residues respectively). A second alignment for TamB has a profile made after just one round of BLAST (bottom line) to exclude any AsmA sequences, which mix with TamB sequences with multiply iterated PSI-BLAST searches. Colour coding as Fig. 3a. d Secondary structural elements in residues 1–95 of the Chorein-N domain (from crystal structure 6CBC – 100% confidence). e and f Secondary structural elements in the N-termini of AsmA (1–120 aa) and TamB (1–125 aa), with confidence of the prediction as in a

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