Fig. 4From: In silico analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the human GJA3 gene associated with congenital cataracta Analysis of evolutionarily conserved amino acid residues of GJA3 by ConSurf. The colour coding bar shows the conservation score, and boxes indicate the high-risk nsSNPs. b Distribution of functional, exposed sites (blue) and conserved, buried sites (orange) of high-risk nsSNPs of GJA3 predicted by ConSurf. c Distribution of high-risk nsSNPs of GJA3 in random coils, alpha helixes, extended strands and beta turns predicted by SOPMA. d SOPMA analysis of the secondary structure of individual amino acid residues in protein produced from the GJA3 gene. The boxes indicate the high-risk nsSNPsBack to article page