From: Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines
Pathway name | Entities | Reactions | ||||
---|---|---|---|---|---|---|
found | ratio | p-value | FDRa | found | ratio | |
Neutrophil degranulation | 56 / 480 | 0.033 | 1.11e-16 | 1.27e-13 | 10 / 10 | 8.01e-04 |
Formation of the cornified envelope | 28 / 138 | 0.01 | 1.94e-14 | 1.11e-11 | 13 / 27 | 0.002 |
Extracellular matrix organization | 42 / 329 | 0.023 | 4.09e-14 | 1.56e-11 | 183 / 318 | 0.025 |
RAB geranylgeranylation | 18 / 68 | 0.005 | 1.39e-11 | 3.99e-09 | 2 / 5 | 4.00e-04 |
Integrin cell surface interactions | 18 / 86 | 0.006 | 5.71e-10 | 1.31e-07 | 45 / 54 | 0.004 |
Keratinization | 28 / 226 | 0.016 | 1.55e-09 | 2.97e-07 | 20 / 34 | 0.003 |
Non-integrin membrane-ECM interactions | 15 / 61 | 0.004 | 1.88e-09 | 3.06e-07 | 19 / 22 | 0.002 |
Platelet degranulation | 21 / 137 | 0.009 | 5.09e-09 | 7.28e-07 | 8 / 11 | 8.81e-04 |
Response to elevated platelet cytosolic Ca2+ | 21 / 144 | 0.01 | 1.19e-08 | 1.51e-06 | 8 / 14 | 0.001 |
Cell-Cell communication | 20 / 133 | 0.009 | 1.61e-08 | 1.84e-06 | 46 / 60 | 0.005 |
Syndecan interactions | 10 / 29 | 0.002 | 4.43e-08 | 4.61e-06 | 12 / 15 | 0.001 |
Axon guidance | 45 / 584 | 0.04 | 4.92e-08 | 4.67e-06 | 147 / 297 | 0.024 |
Developmental Biology | 73 / 1207 | 0.084 | 6.41e-08 | 5.64e-06 | 167 / 511 | 0.041 |
Post-translational protein phosphorylation | 17 / 109 | 0.008 | 1.16e-07 | 9.37e-06 | 1 / 1 | 8.01e-05 |
Cell junction organization | 15 / 94 | 0.007 | 4.83e-07 | 3.67e-05 | 26 / 37 | 0.003 |
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 17 / 127 | 0.009 | 9.31e-07 | 6.61e-05 | 1 / 14 | 0.001 |
Transport of small molecules | 58 / 963 | 0.067 | 1.97e-06 | 1.32e-04 | 97 / 438 | 0.035 |
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | 6 / 13 | 9.01e-04 | 4.45e-06 | 2.80e-04 | 2 / 3 | 2.40e-04 |
ATF6 (ATF6-alpha) activates chaperone genes | 6 / 15 | 0.001 | 9.96e-06 | 5.98e-04 | 3 / 5 | 4.00e-04 |
Vesicle-mediated transport | 49 / 824 | 0.057 | 1.83e-05 | 0.001 | 115 / 251 | 0.02 |
Adherens junctions interactions | 8 / 35 | 0.002 | 1.93e-05 | 0.001 | 16 / 16 | 0.001 |
ATF6 (ATF6-alpha) activates chaperones | 6 / 17 | 0.001 | 2.00e-05 | 0.001 | 4 / 10 | 8.01e-04 |
Transport of inorganic cations/anions and amino acids/oligopeptides | 17 / 165 | 0.011 | 2.71e-05 | 0.001 | 23 / 75 | 0.006 |
Platelet activation, signaling and aggregation | 24 / 293 | 0.02 | 2.78e-05 | 0.001 | 33 / 114 | 0.009 |
Innate Immune System | 69 / 1328 | 0.092 | 2.80e-05 | 0.001 | 88 / 696 | 0.056 |