Fig. 4
From: Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease
Detection of changes in asymmetry in mutant structures. For this analysis, we selected all structures exhibiting the K7R, I46V, I54M, V62A, V71I, I82F, I84V, L90M, or L99F mutation. a presents matrices summarizing the positions exhibiting changes in asymmetry for the nine selected mutations. The matrix rows present mutant and matrix columns corresponding to PR2 positions. A matrix cell indicates the number of mutant structures (from 0 to 5) exhibiting changes in asymmetry at a given position. Positions in blue exhibit changes in asymmetry in all mutants. PR2 regions are presented at the top of the figure and are colored according to the color code of Fig. 1. b Localization of positions exhibiting changes in asymmetry in the PR2 structures. Proteins are displayed in cartoon mode and colored blue. Mutations are displayed with sticks and colored red. Positions exhibiting changes in asymmetry in the mutant structures relative to the wild-type structure are displayed in stick mode. Only positions exhibiting changes in asymmetry in at least one structure of all mutants harboring the studied mutations are indicated in the 3D structure of PR2