Fig. 1

Functional and structural characterization of recombinant APETx1 in patch-clamp recordings. a, b Current traces of hERG elicited by two different depolarization pulses, 0 mV (a) and 60 mV (b), before (black) and after (red) the administration of 10 μM APETx1. Voltage protocol is illustrated at the bottom of each current trace. c Normalized G-V curves (mean ± SEM) of hERG in the presence or absence of different APETx1 concentrations. d The ΔV_1/2 values of different concentrations of APETx1; these values indicate the toxin-induced shift of the half-maximal activation voltage of hERG