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Fig. 6 | BMC Molecular and Cell Biology

Fig. 6

From: Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog

Fig. 6

Restoring the defects of the mutant with use of the mitochondrial therapeutic idebenone. The oxygen consumption rates of permeabilized cells treated with DMSO or idebenone are shown (A). The rates per million cells in response to injection of substrates, inhibitor, or drug are depicted. The mean oxygen consumption values were compared between the idebenone treatment and DMSO control. The p values for the differences between the mean values of DMSO control versus idebenone treatment were 0.8689, 0.7605, 0.9394, 0.1250, 0.0119, 0.0508, 0.0323, 0.0148, and 0.1084 respectively for G/M, rotenone, succinate, 1 μM idebenone, 1st dose of 5 μM idebenone, 2nd dose of 5 μM idebenone, 3rd dose of 5 μM idebenone, ADP, and FCCP. The number of cells recovered from the mutant cultures treated with 1 μM idebenone or DMSO are shown (B). Error bars represent the SE of the mean.

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