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Fig. 1 | BMC Molecular and Cell Biology

Fig. 1

From: Effect of Voacamine upon inhibition of hypoxia induced fatty acid synthesis in a rat model of methyln-nitrosourea induced mammary gland carcinoma

Fig. 1

Docked pose of VOA with PHD-2 and in silico pharmacokinetics. VOA was docked with PHD2 protein (PDB ID: 2G19) with Autodock 4.2, and calculated binding energy was found to be −9.46 kCal/mol. The drug has hydrogen bonding interaction with LEU271, THR218, LEU193, LEU191, HIS282, ARG282, ARG281, ALA190, LEU188, PHE213, GLY213, LEU214, GLU217, ASP278, SER275, and SER214 type of amino acids. In silico, ADME was tested with pkCSM software (http://biosig.unimelb.edu.au/pkcsm/prediction_single/adme_1604411699.32), and results are presented in Table 1

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