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Fig. 3 | BMC Molecular and Cell Biology

Fig. 3

From: Effect of Voacamine upon inhibition of hypoxia induced fatty acid synthesis in a rat model of methyln-nitrosourea induced mammary gland carcinoma

Fig. 3

Effect of VOA on the morphology of mammary gland carmine staining. G1&G7-Carmine staining of normal control (G1) and DMSO (G7) administered rats showing very less branching of ducts, terminal end duct (ted), terminal bud (tb), normal lateral bud (lb), alveolar buds (ab), B-Carmine staining toxic control (G2) rats showing excessive branching of mammary gland ducts, a high number of ab and lobules (lo) along with tb and lb. C-G3 rats treated with a low dose of VOA showing very less branching of mammary gland ducts and few numbers of ab and no lo formation was noted, D-G4-Rats treated with a high dose of VOA showing tb, lb, ab, and lo, E-G5-Rats treated with TMX showing lb, tb, ab, and lo, F-G6-Rats treated with combination therapy of VOA and TMX showing along with tb, lb, ted and ab only.

H&E staining: G1-G7 -Histology of G1 and G7 rats were showing the normal shape and of lactiferous duct (ld) and adipocytes, B-G2-Histology of rats showing damaged lactiferous duct (dld) and distorted shape of adipocytes (ad), C-G3-Rats were showing normal shape of ld, and ad, D-G4-VOA high dose treated rats showing regenerated lactiferous duct (rld) and ad, E-Rats treated with TMX showing rld and ad, F-G6-VOA and TMX treated rats showing the normal shape of ld and ad

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