Skip to main content

Table 3 Effect of VOA and TMX on antioxidant markers

From: Effect of Voacamine upon inhibition of hypoxia induced fatty acid synthesis in a rat model of methyln-nitrosourea induced mammary gland carcinoma

Groups

TBAR’s (nm of MDA/μg of protein

GSH (mg %)

SOD (units of SOD/mg of protein)

Catalase (nm of H2O2/ min/mg of protein)

PC nmol/mg of protein

G1 [Normal control, normal saline 2 ml/kg, p.o.]

489.70 ± 56.4***

0.71 ± 0.3***

0.03 ± 0.01***

0.43 ± 0.2***

21.30 ± 6.4***

G2 [toxic control, MNU 50 mg/kg, i.p]

868.6 ± 67.31

0.63 ± 0.03

0.022 ± 0.00

0.19 ± 0.036

57.08 ± 7.34

G3 [MNU 50 mg/kg, i.p. + VOA 1 mg/kg, s.c.]

304.5 ± 54.9***

1.4 ± 0.09***

0.037 ± 0.00**

0.34 ± 0.02*

24.4 ± 3.4***

G4 [MNU 50 mg/kg, i.p. + VOA 2 mg/kg, s,c.]

698.56 ± 90***

0.72 ± 0.093

0.021 ± 0.00

0.28 ± 0.06

45.3 ± 0.4

G5 [MNU 50 mg/kg, i.p. + TMX 8 mg/kg, p.o.]

592.4 ± 25.8***

0.80 ± 0.09

0.034 ± 0.001**

0.34 ± 0.12

35.6 ± 0.6

G6 [MNU 50 mg/kg,i.p. + VOA 1 mg/kg, s.c. + TMX 1 mg/kg s.c.]

207.5 ± 54.9***

1.9 ± 0.09***

0.07 ± 0.00**

0.56 ± 0.06*

27.3 ± 0.4***

G7 [dummy control, 3% DMSO solution s.c]

379.70 ± 56.4***

0.71 ± 0.3***

0.06 ± 0.01*

0.45 ± 0.2***

23.30 ± 6.4***

  1. Values are presented as Mean ± SD, each group contains 6 animals. Comparisons were made on the basis of the one-way ANOVA followed by Bonferroni test. All groups were compared to the toxic control group (*p < 0.05, **p < 0.01, ***p < 0.001)