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Structure and function of macromolecules

  1. The SARS-CoV-2 virus, the causative agent of COVID-19, consists of an assembly of proteins that determine its infectious and immunological behavior, as well as its response to therapeutics. Major structural bi...

    Authors: Luciano Kagami, Joel Roca-Martínez, Jose Gavaldá-García, Pathmanaban Ramasamy, K. Anton Feenstra and Wim F. Vranken

    Citation: BMC Molecular and Cell Biology 2021 22:23

    Content type: Database

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  2. Reef-building corals regularly experience changes in intra- and extracellular H+ concentrations ([H+]) due to physiological and environmental processes. Stringent control of [H+] is required to maintain the homeo...

    Authors: Laura Capasso, Philippe Ganot, Víctor Planas-Bielsa, Sylvie Tambutté and Didier Zoccola

    Citation: BMC Molecular and Cell Biology 2021 22:18

    Content type: Research article

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  3. The avian eggshell is a natural protective envelope that relies on the phenomenon of biomineralization for its formation. The shell is made of calcium carbonate in the form of calcite, which contains hundreds ...

    Authors: J. Gautron, L. Stapane, N. Le Roy, Y. Nys, A. B. Rodriguez-Navarro and M. T. Hincke

    Citation: BMC Molecular and Cell Biology 2021 22:11

    Content type: Review

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    The Correction to this article has been published in BMC Molecular and Cell Biology 2021 22:14

  4. One striking feature of the large KRAB domain-containing zinc finger protein (KZFP) family is its rapid evolution, leading to hundreds of member genes with various origination time in a certain mammalian genom...

    Authors: Pan Shen, Aishi Xu, Yushan Hou, Huqiang Wang, Chao Gao, Fuchu He and Dong Yang

    Citation: BMC Molecular and Cell Biology 2021 22:7

    Content type: Research article

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  5. Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1. APETx1 is a 42-residue p...

    Authors: Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada and Masanori Osawa

    Citation: BMC Molecular and Cell Biology 2021 22:3

    Content type: Research article

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  6. The CD4 protein is an important surface marker of T lymphocytes, which can mediate the antigen presentation process by interacting with MHC II and TCR molecules in human and mouse.

    Authors: Weiya Zhang, Juan Ni, Jie Zhang, Lu Zhang, Huanhuan Zhou, Changzhi Zhao, Mengjin Zhu, Haiyan Wang, Jianlin Han, Xinyun Li and Shuhong Zhao

    Citation: BMC Molecular and Cell Biology 2020 21:91

    Content type: Research article

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  7. The zoonotic worm parasite Fasciola hepatica secretes an abundance of cathepsin L peptidases that are associated with virulence, invasiveness, feeding and migration. The peptidases are produced as inactive zymoge...

    Authors: Izanara C. Pritsch, Irina G. Tikhonova, Heather L. Jewhurst, Orla Drysdale, Krystyna Cwiklinski, Marcelo B. Molento, John P. Dalton and Carolina De M. Verissimo

    Citation: BMC Molecular and Cell Biology 2020 21:90

    Content type: Research article

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  8. Type A influenza viruses are contagious and even life-threatening if left untreated. So far, no broadly protective vaccine is available due to rapid antigenic changes and emergence of new subtypes of influenza...

    Authors: Davod Jafari, Sara Malih, Mohammad Mahmoudi Gomari, Marzieh Safari, Rasool Jafari and Mohammad Morad Farajollahi

    Citation: BMC Molecular and Cell Biology 2020 21:89

    Content type: Research article

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  9. Like most major enzyme families, the M14 family of metallocarboxypeptidases (MCPs) contains a number of pseudoenzymes predicted to lack enzyme activity and with poorly characterized molecular function. The gen...

    Authors: R. Christian McDonald, Matthew J. Schott, Temitope A. Idowu and Peter J. Lyons

    Citation: BMC Molecular and Cell Biology 2020 21:86

    Content type: Research article

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  10. Pneumonia ranks as one of the main infectious sources of mortality among kids under 5 years of age, killing 2500 a day; late research has additionally demonstrated that mortality is higher in the elderly. A fe...

    Authors: Olalekan Olanrewaju Bakare, Marshall Keyster and Ashley Pretorius

    Citation: BMC Molecular and Cell Biology 2020 21:82

    Content type: Research article

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  11. MreB is a bacterial ortholog of actin and forms mobile filaments underneath the cell membrane, perpendicular to the long axis of the cell, which play a crucial role for cell shape maintenance. We wished to vis...

    Authors: Simon Dersch, Christian Reimold, Joshua Stoll, Hannes Breddermann, Thomas Heimerl, Hervé Joel Defeu Soufo and Peter L. Graumann

    Citation: BMC Molecular and Cell Biology 2020 21:76

    Content type: Research article

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  12. G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological ro...

    Authors: Shivani Kumar, Divya Choudhary, Anupam Patra, Neel Sarovar Bhavesh and Perumal Vivekanandan

    Citation: BMC Molecular and Cell Biology 2020 21:67

    Content type: Research article

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  13. It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivota...

    Authors: Matthias F. Schneider, Mohammad A. Fallah, Christian Mess, Tobias Obser, Reinhard Schneppenheim, Alfredo Alexander-Katz, Stefan W. Schneider and Volker Huck

    Citation: BMC Molecular and Cell Biology 2020 21:64

    Content type: Research article

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  14. Advances in the study of chromosome conformation capture technologies, such as Hi-C technique - capable of capturing chromosomal interactions in a genome-wide scale - have led to the development of three-dimen...

    Authors: Oluwatosin Oluwadare, Max Highsmith, Douglass Turner, Erez Lieberman Aiden and Jianlin Cheng

    Citation: BMC Molecular and Cell Biology 2020 21:60

    Content type: Database

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    The Correction to this article has been published in BMC Molecular and Cell Biology 2020 21:62

  15. The main challenge in cancer research is the identification of different omic variables that present a prognostic value and personalised diagnosis for each tumour. The fact that the diagnosis is personalised o...

    Authors: Jose Liñares-Blanco, Cristian R. Munteanu, Alejandro Pazos and Carlos Fernandez-Lozano

    Citation: BMC Molecular and Cell Biology 2020 21:52

    Content type: Research article

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  16. Β-glucosidases are key enzymes used in second-generation biofuel production. They act in the last step of the lignocellulose saccharification, converting cellobiose in glucose. However, most of the β-glucosida...

    Authors: Diego Mariano, Naiara Pantuza, Lucianna H. Santos, Rafael E. O. Rocha, Leonardo H. F. de Lima, Lucas Bleicher and Raquel Cardoso de Melo-Minardi

    Citation: BMC Molecular and Cell Biology 2020 21:50

    Content type: Database

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  17. Following the recent outbreak of the new coronavirus pandemic (Covid-19), the rapid determination of the structure of the homo-trimeric spike glycoprotein has prompted the study reported here. The aims were to...

    Authors: Elliot D. Drew and Robert W. Janes

    Citation: BMC Molecular and Cell Biology 2020 21:49

    Content type: Research article

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  18. Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of...

    Authors: Pierre Laville, Sandrine Fartek, Natacha Cerisier, Delphine Flatters, Michel Petitjean and Leslie Regad

    Citation: BMC Molecular and Cell Biology 2020 21:46

    Content type: Research article

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  19. Detailed structural knowledge of enzyme-inhibitor complexes trapped in intermediate state is the key for a fundamental understanding of reaction mechanisms taking place in enzymes and is indispensable as a str...

    Authors: Peter Agback, Esmeralda Woestenenk and Tatiana Agback

    Citation: BMC Molecular and Cell Biology 2020 21:38

    Content type: Research article

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  20. Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a recently identified cell adhesion molecule which is predominantly expressed by epithelial cells of the intestine and the kidney. Its e...

    Authors: Christian Hartmann, Ysabel Alessa Schwietzer, Daniel Kummer, Nils Kirschnick, Esther Hoppe, Eva-Maria Thüring, Mark Glaesner-Ebnet, Frauke Brinkmann, Volker Gerke, Stefan Reuter, Masanori Nakayama and Klaus Ebnet

    Citation: BMC Molecular and Cell Biology 2020 21:30

    Content type: Research article

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  21. TgDCX is a doublecortin-domain protein associated with the conoid fibers, a set of strongly curved non-tubular tubulin-polymers in Toxoplasma. TgDCX deletion impairs conoid structure and parasite invasion. TgDCX ...

    Authors: Jacqueline M. Leung, Eiji Nagayasu, Yu-Chen Hwang, Jun Liu, Phillip G. Pierce, Isabelle Q. Phan, Robin A. Prentice, John M. Murray and Ke Hu

    Citation: BMC Molecular and Cell Biology 2020 21:8

    Content type: Research article

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  22. Brucella is a facultative intracellular pathogen responsible for zoonotic disease brucellosis. Little is known about the molecular basis of Brucella adherence to host cells. In the present study, the possible rol...

    Authors: Yasmin ElTahir, Amna Al-Araimi, Remya R. Nair, Kaija J. Autio, Hongmin Tu, Jack C. Leo, Waleed Al-Marzooqi and Eugene H. Johnson

    Citation: BMC Molecular and Cell Biology 2019 20:55

    Content type: Research article

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    The Correction to this article has been published in BMC Molecular and Cell Biology 2020 21:16

  23. Reactive oxygen species (ROS) produce different lesions in DNA by ROS-induced DNA damage. Detection and quantification of 8-oxo-7,8-dihydroguanine (8-oxoG) within cells are important for study. Human ribosomal...

    Authors: Dong Min Kang, Jong-Il Shin, Ji Beom Kim, Kyungho Lee, Ji Hyung Chung, Hye-Won Yang, Kil-Nam Kim and Ye Sun Han

    Citation: BMC Molecular and Cell Biology 2019 20:54

    Content type: Research article

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  24. Olfactomedin-1 (Olfm1; also known as Noelin or Pancortin) is a highly-expressed secreted brain and retina protein and its four isoforms have different roles in nervous system development and function. Structur...

    Authors: Matti F. Pronker, Hugo van den Hoek and Bert J. C. Janssen

    Citation: BMC Molecular and Cell Biology 2019 20:50

    Content type: Research article

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  25. Docking large ligands, and especially peptides, to protein receptors is still considered a challenge in computational structural biology. Besides the issue of accurately scoring the binding modes of a protein-...

    Authors: Didier Devaurs, Dinler A Antunes, Sarah Hall-Swan, Nicole Mitchell, Mark Moll, Gregory Lizée and Lydia E Kavraki

    Citation: BMC Molecular and Cell Biology 2019 20:42

    Content type: Research article

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  26. Microtubule proteins are able to produce electromagnetic fields and have an important role in memory formation, and learning. Therefore, microtubules have the potential to be affected by exogenous electromagne...

    Authors: Dariush Gholami, Gholamhossein Riazi, Rouhollah Fathi, Mohsen Sharafi and Abdolhossein Shahverdi

    Citation: BMC Molecular and Cell Biology 2019 20:41

    Content type: Research article

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  27. The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and...

    Authors: Melissa C. Holt, Chi S. Ho, M. Inés Morano, Stephen D. Barrett and Adam J. Stein

    Citation: BMC Molecular and Cell Biology 2019 20:37

    Content type: Research article

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  28. Whole-proteome distributions of protein isoelectric point (pI) values in different organisms are bi- or trimodal with some variations. It was suggested that the observed multimodality of the proteome-wide pI d...

    Authors: Atsushi Kurotani, Alexander A. Tokmakov, Ken-Ichi Sato, Vasily E. Stefanov, Yutaka Yamada and Tetsuya Sakurai

    Citation: BMC Molecular and Cell Biology 2019 20:36

    Content type: Research article

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  29. HPV16 infection is one of the main risk factors involved in the development of cervical cancer, mainly due to the high oncogenic potential of the viral proteins E6 and E7, which are involved in the different p...

    Authors: Hugo Alberto Rodríguez-Ruiz, Olga Lilia Garibay-Cerdenares, Berenice Illades-Aguiar, Sarita Montaño, Xiaowei Jiang and Marco Antonio Leyva-Vázquez

    Citation: BMC Molecular and Cell Biology 2019 20:35

    Content type: Research article

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  30. The discovery of thermostable DNA polymerases such as Taq DNA polymerase revolutionized amplification of DNA by polymerase chain reaction methods that rely on thermal cycling for strand separation. These metho...

    Authors: Yvonne Piotrowski, Man Kumari Gurung and Atle Noralf Larsen

    Citation: BMC Molecular and Cell Biology 2019 20:31

    Content type: Research article

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  31. Several human cancers, especially cervical cancer are caused by the infection of high risk strains of human papillomaviruses (HPV), notably HPV16. It is implicated that the oncoprotein E6 expressed from HPV, i...

    Authors: Srikanth Kolluru, Rosemary Momoh, Lydia Lin, Jayapal Reddy Mallareddy and John L. Krstenansky

    Citation: BMC Molecular and Cell Biology 2019 20:30

    Content type: Research article

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  32. CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L expressed on T cells results...

    Authors: Maria A. Argiriadi, Lorenzo Benatuil, Ievgeniia Dubrovska, David A. Egan, Lei Gao, Amy Greischar, Jennifer Hardman, John Harlan, Ramesh B. Iyer, Russell A. Judge, Marc Lake, Denise C. Perron, Ramkrishna Sadhukhan, Bernhard Sielaff, Silvino Sousa, Rui Wang…

    Citation: BMC Molecular and Cell Biology 2019 20:29

    Content type: Research article

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  33. Protein tyrosine phosphatase PTPN13, also known as PTP-BL in mice, is a large multi-domain non-transmembrane scaffolding protein with a molecular mass of 270 kDa. It is involved in the regulation of several ce...

    Authors: Markus Dicks, Gerd Kock, Bastian Kohl, Xueyin Zhong, Stefanie Pütz, Rolf Heumann, Kai S. Erdmann and Raphael Stoll

    Citation: BMC Molecular and Cell Biology 2019 20:23

    Content type: Research article

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  34. The manual classification of protein domains is approaching its 20th anniversary. ECOD is our mixed manual-automatic domain classification. Over time, the types of proteins which require manual curation has ch...

    Authors: R. Dustin Schaeffer, Lisa Kinch, Kirill E. Medvedev, Jimin Pei, Hua Cheng and Nick Grishin

    Citation: BMC Molecular and Cell Biology 2019 20:18

    Content type: Database

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  35. Focal Adhesion Kinase (FAK) is a major cancer drug target that is involved in numerous aspects of tumor progression and survival. While multiple research groups have developed ATP-competitive small molecule in...

    Authors: Timothy Marlowe, Alexey Dementiev, Sheila Figel, Andrew Rivera, Michael Flavin and William Cance

    Citation: BMC Molecular and Cell Biology 2019 20:10

    Content type: Research article

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