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  1. Human induced pluripotent stem cells (iPSC) have opened new avenues for regenerative medicine. Consequently, iPSC-derived motor neurons have emerged as potentially viable therapies for spinal cord injuries and...

    Authors: Emilia Solomon, Katie Davis-Anderson, Blake Hovde, Sofiya Micheva-Viteva, Jennifer Foster Harris, Scott Twary and Rashi Iyer

    Citation: BMC Molecular and Cell Biology 2021 22:13

    Content type: Research article

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  2. Breast cancer 2, early onset (BRCA2) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations in BRCA2 and d...

    Authors: Yasunaga Yoshikawa, Hajime Kozuma, Masami Morimatsu, Kaori Sugawara and Koichi Orino

    Citation: BMC Molecular and Cell Biology 2021 22:2

    Content type: Research article

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  3. Caenorhabditis elegans is an excellent model organism for biological research, but its contributions to biochemical elucidation of eukaryotic transcription mechanisms have been limited. One of the biggest obstacl...

    Authors: Phillip Wibisono, Yiyong Liu and Jingru Sun

    Citation: BMC Molecular and Cell Biology 2020 21:87

    Content type: Methodology article

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  4. The effects of diverse stresses ultimately alter the structures and functions of proteins. As molecular chaperones, heat shock proteins (HSPs) are a group of highly conserved proteins that help in the refoldin...

    Authors: Xin Zhang, Yuting Li, Yulong Sun, Mingxing Guo, Jianjun Feng, Yilei Wang and Ziping Zhang

    Citation: BMC Molecular and Cell Biology 2020 21:83

    Content type: Research article

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  5. Local Chinese local pig breeds have thinner muscle fiber and higher intramuscular-fat (IMF) content. But its regulation mechanism has not been discussed in-depth. Studies indicated that long non coding RNAs (l...

    Authors: Jing Wang, Ming-yue Chen, Jun-feng Chen, Qiao-ling Ren, Jia-qing Zhang, Hai Cao, Bao-song Xing and Chuan-ying Pan

    Citation: BMC Molecular and Cell Biology 2020 21:77

    Content type: Research article

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  6. The Werner syndrome protein (WRN) belongs to the RecQ family of helicases and its loss of function results in the premature aging disease Werner syndrome (WS). We previously demonstrated that an early cellular...

    Authors: Juan Manuel Iglesias-Pedraz, Diego Matia Fossatti-Jara, Valeria Valle-Riestra-Felice, Sergio Rafael Cruz-Visalaya, Jose Antonio Ayala Felix and Lucio Comai

    Citation: BMC Molecular and Cell Biology 2020 21:71

    Content type: Research article

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  7. We have previously reported 18S and 25S ribosomal RNA molecules in Candida albicans resistant to processive 5′ → 3′ exonuclease, appearing as cells approached stationary growth phase. Initial analysis pointed to ...

    Authors: Jacob Fleischmann, Miguel A. Rocha, Peter V. Hauser, Bhavani S. Gowda and Mary Grace D. Pilapil

    Citation: BMC Molecular and Cell Biology 2020 21:59

    Content type: Research article

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  8. Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy. This study aimed to investigate the e...

    Authors: Jing Ai, Jian Ma, Zhi-Qing Chen, Jun-Hui Sun and Ke Yao

    Citation: BMC Molecular and Cell Biology 2020 21:57

    Content type: Research article

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  9. The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and p...

    Authors: Sara Martire, Jennifer Nguyen, Aishwarya Sundaresan and Laura A. Banaszynski

    Citation: BMC Molecular and Cell Biology 2020 21:55

    Content type: Research article

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  10. Trichomonas vaginalis, the causative agent of a prevalent urogenital infection in humans, is an evolutionarily divergent protozoan. Protein-coding genes in T. vaginalis are largely controlled by two core promoter...

    Authors: Shuqi E. Wang, Anna E. S. Brooks, Anthony M. Poole and Augusto Simoes-Barbosa

    Citation: BMC Molecular and Cell Biology 2020 21:54

    Content type: Research article

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  11. Klotho is a multifunctional protein, which exists both in a membrane bound and a soluble form. In renal tubules, Klotho is involved in cell senescence, anti-oxidant response, and renal fibrosis, thus regulatio...

    Authors: Yan Li, Yong Liu, Kailong Wang, Yinghui Huang, Wenhao Han, Jiachuan Xiong, Ke Yang, Mingying Liu, Tangli Xiao, Chi Liu, Ting He, Xianjin Bi, Jingbo Zhang, Bo Zhang and Jinghong Zhao

    Citation: BMC Molecular and Cell Biology 2020 21:45

    Content type: Research article

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  12. In the poultry and livestock industries, precise genetic information is crucial for improving economic traits. Thus, functional genomic studies help to generate faster, healthier, and more efficient animal pro...

    Authors: Jeong Hyo Lee, Seo Woo Kim, Ji Seon Han, Seung Pyo Shin, Sang In Lee and Tae Sub Park

    Citation: BMC Molecular and Cell Biology 2020 21:40

    Content type: Research article

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  13. Transcriptional responses required to maintain cellular homeostasis or to adapt to environmental stress, is in part mediated by several nucleic-acid associated proteins. In this study, we sought to establish a...

    Authors: Nastassja L. Kriel, Tiaan Heunis, Samantha L. Sampson, Nico C. Gey van Pittius, Monique J. Williams and Robin M. Warren

    Citation: BMC Molecular and Cell Biology 2020 21:19

    Content type: Research article

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  14. dADD1 and dXNP proteins are the orthologs in Drosophila melanogaster of the ADD and SNF2 domains, respectively, of the ATRX vertebrate’s chromatin remodeler, they suppress position effect variegation phenotypes a...

    Authors: Silvia Meyer-Nava, Amada Torres, Mario Zurita and Viviana Valadez-Graham

    Citation: BMC Molecular and Cell Biology 2020 21:17

    Content type: Research article

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  15. Gene transfer by electroporation is an established method for the non-viral mediated transfection of mammalian cells. Primary cells pose a particular challenge for electroporation-mediated gene transfer, since...

    Authors: Iqbal Hyder, Shahin Eghbalsaied and Wilfried A. Kues

    Citation: BMC Molecular and Cell Biology 2020 21:9

    Content type: Methodology article

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  16. ZNF143 is an important transcriptional regulator protein conserved in metazoans and estimated to bind over 2000 promoter regions of both messenger RNA and small nuclear RNA genes. The use of zebrafish is a use...

    Authors: Laura Huning and Gary R. Kunkel

    Citation: BMC Molecular and Cell Biology 2020 21:3

    Content type: Research article

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  17. In the bovine placenta, intimate fetomaternal contacts are restricted to discrete placentomes. Here, widely branched fetal chorionic villi interdigitate with corresponding maternal caruncular crypts. The fetal...

    Authors: Marina Polei, Juliane Günther, Dirk Koczan and Rainer Fürbass

    Citation: BMC Molecular and Cell Biology 2020 21:1

    Content type: Research article

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  18. The HongXin radish (Raphanus sativus L.), which contains the natural red pigment (red radish pigment), is grown in the Fuling district of Chongqing City. However, the molecular mechanisms underlying anthocyanin s...

    Authors: Jian Gao, Wen-Bo Li, Hong-Fang Liu and Fa-Bo Chen

    Citation: BMC Molecular and Cell Biology 2019 20:45

    Content type: Research article

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  19. Endothelial cells (ECs) play a key role in tissue homeostasis, in several pathological conditions, and specifically in the control of vascular functions. ECs are frequently used as in vitro model systems for c...

    Authors: Olli-Pekka A. Hätinen, Johanna E. Lähteenvuo, Henna J. Korpela, Juho J. Pajula and Seppo Ylä-Herttuala

    Citation: BMC Molecular and Cell Biology 2019 20:32

    Content type: Methodology article

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  20. Podocyte plays an important role in maintaining the integrity and function of the glomerular filtration barrier. Various studies reported that forkhead transcription factor (Fox) O1 played a key role in anti-o...

    Authors: Hongkun Wang, Yanhui Zhang, Fangfang Xia, Wei Zhang, Peng Chen and Guoan Yang

    Citation: BMC Molecular and Cell Biology 2019 20:27

    Content type: Research article

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  21. Classic dendritic cells (cDCs) play a central role in the immune system by processing and presenting antigens to activate T cells, and consist of two major subsets: CD141+ cDC (cDC1) and CD1c+ cDC (cDC2). A popul...

    Authors: Wenji Ma, Jaeyop Lee, Daniel Backenroth, Yu Jerry Zhou, Erin Bush, Peter Sims, Kang Liu and Yufeng Shen

    Citation: BMC Molecular and Cell Biology 2019 20:20

    Content type: Research article

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  22. MicroRNAs (miRNAs) are increasingly being identified as modulatory molecules for physiological and pathological processes in muscle. Here, we investigated whether miRNAs influenced the expression of the stress...

    Authors: Bilal A. Mir, Rabia Islam, Ming Kalanon, Aaron P. Russell and Victoria C. Foletta

    Citation: BMC Molecular and Cell Biology 2019 20:12

    Content type: Research article

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  23. Egg formation takes place in the oviduct of laying hens over a 24 h period. Infectious bronchitis virus (IBV) causes pathological lesions in the chicken oviduct. In the current study, mitochondrial counts were...

    Authors: Samiullah Khan, Juliet Roberts and Shu-Biao Wu

    Citation: BMC Molecular and Cell Biology 2019 20:3

    Content type: Research article

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